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Maximum-likelihood approaches for mapping QTL.
For a complete understanding of genetic determination of quantitative traits, it is necessary to answer the following questions: how many QTL are involved, how many of them are statistically significant, where do they lie in the genome, and how large are their effect sizes. Efficient, systematic mapping of QTL using multi-locus tests based on biometrical considerations is currently hampered by the need for large sample sizes. We propose an alternative procedure, which does not require stringent assumptions about QTL density in the genome. Instead, the procedure works with test statistics based on maximum-likelihood estimates. Use of an explicit modeling of the phenotypic values conditional on markers allows to apply standard methods of QTL detection. We report the results of simulations showing that the procedures are sensitive enough to identify all the causal genes.Pyrnitzia
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